3-Dimensional microarrays are created in a nanoporous polymer film. The microarrays are stabilized by covalent attachment over a click-chemistry approach and exhibit an enhanced dynamic range for the detection of antibody binding due to a higher amount of binding sites in the nanoporous film compared to flat substrates with conventional 2-dimensional surface arrays.
Click-Chemistry Immobilized 3D-infused Microarrays in Nanoporous Polymer Substrates
M. Hirtz, W. Feng, H. Fuchs, P. A. Levkin
Adv. Mater. Interfaces 3 (2016) 1500469