Talk given by Dr. Matthias Gabriel Qatar Cardiovascular Research Center Doha, Qatar Abstract: Many approved materials for medical use – including polymers and metals – are not ideal regarding their biocompatibility. Cell-adhesive and low fouling properties are key to most applications, e.g. in tissue engineering and in blood-contacting devices. Besides plasma technologies various wet-chemistry methods are employed to endow surfaces with appropriate features while the materials bulk properties are largely unaffected. Covalent conjugation of peptides derived from extracellular matrix proteins, is a promising strategy to promote cell-adhesion and colonization. In contrast, many medical devices suffer from unspecific protein adsorption which mediates unwanted adhesion of platelets and bacteria. This issue may be addressed by anti-fouling surfaces, mostly accomplished via immobilization of hydrophilic polymers. Combining both, cell-adhesiveness and anti-fouling modification, results in surfaces that promote specific cell-adhesion while simultaneously reducing the attachment of undesired cells.

This event is part of the eventgroup INT Talks

Homepage
https://www.int.kit.edu/events.php

Speaker
Dr. Matthias Gabriel

Qatar Cardiovascular Research Center, Doha, Qatar
http://www.qatarcardio.org/scientist-dr-matthias-gabriel/

Organizer
Dr. Dr. Michael Hirtz
Institute of Nanotechnology (INT)
Karlsruhe Institute of Technology (KIT)
Eggenstein-Leopoldshafen
Mail: michael hirtz ∂does-not-exist.kit edu

Targetgroup
Interested / Everyone