Talk given by Dr. Nadia Benkirane-Jessel Research Director, DR1 Inserm INSERM (French National Institute of Health and Medical Research) Université de Strasbourg Strasbourg, France Abstract: Recently, We have reported an active nanostructured collagen implant reinforced with human stem cells for bone regeneration. In our group, we have reported a "Smart Hybrid Materials Equipped with Nanoreservoirs of Therapeutics and stem cells spheroids ". This unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine. The cell contact-dependent bioerodable nanoreservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated cell-therapy implants capable of robust and durable regeneration of a broad variety of tissues. Clinical trial: phase 1 Horizon 2020, (FR, UK, SP, SW) submitted Feasibility and safety assessment of a therapeutic implant based on a bioactive collagen membrane and autologous mesenchymal stem cells derived from bone marrow for the treatment of femoral cartilage isolated lesions 1. Mendoza-Palomares, S. Facca, C. Cortez, C, N. Messadeq, A. Dierich, A.P.R. Johnston, Proc. Natl. D. Mainard, Acad. Sci. J.C. USA. Voegel, 2010, F. Caruso, N. Benkirane-Jessel, Active multilayered capsules for in vivo bone formation. Proc. Natl. Acad. Sci. USA. 2010, 107, 3406. 2. Facca S, Lahiri D, Fioretti F, Agarwal A, Benkirane-Jessel N, In vivo osseointegration of nano-designed composite coatings on titanium implants. ACS Nano 2011, 5: 4790-4799. 3. C. Mendoza, A. Ferrand, S. Facca, F. Fioretti, D. Mainard, N. Benkirane-Jessel, Smart hybrid materials equipped by nanoreservoirs of therapeutics. ACS Nano. 2012, 6, 483.3. 4.  Eap S, Ferrand F, Schiavi J, Keller L, Fioretti F, Ladam G, Benkirane-Jessel N. Collagen implants equipped by “fishscale”- like nanoreservoirs of growth factors for bone regeneration. Nanomedicine. 2014, 9, 1253–1261 5. Keller L, Schiavi J, De Isla-Martinez N, Morand D, Mainard D, Schwinté P, Benkirane-Jessel N. Active and nanostructured collagen implant reinforced with human mesenchymal stem cells microtissues for bone regenerative nanomedicine. Nanomedicine. 2015 (in press) 6. Keller L, Wagner Q, Pugliano M, Breda P, Ehlinger M, Schwinté P and Benkirane-Jessel N. Bi-layered Nano Active Implant with Hybrid Stem Cell Microtissues for Tuned Cartilage Hypertrophy. Journal of Stem Cell Research and Therapeutics. 2015. 1(1): 00004. DOI: 10.15406/jsrt.2015.01.00004. 7. Keller L, Wagner Q, Schwinté P, Benkirane-Jessel N.  Double Compartmented and Hybrid Implant Outfitted with Well-Organized 3D Stem Cells for Osteochondral Regenerative Nanomedicine. Nanomedicine (Lond) 2015 10, 2833-2845

This event is part of the eventgroup INT Talks

Homepage
https://www.int.kit.edu/events.php

Speaker
Dr. Nadia Benkirane-Jessel

INSERM (French National Institute of Health and Medical Research) Université de Strasbourg
http://www.regmed.fr/

Organizer
NanoMat Cluster
Karlsruher Institut für Technologie (KIT)
Hermann-von-Helmholtz-Platz 1
76344 Eggenstein-Leopoldshafen
Mail: nathalie matter-koenig ∂does-not-exist.kit edu

Targetgroup
Interested / Everyone