Scanning Probe Lithography for Biomaterials and Bioelectronics

Our group focuses on the advancement and application of dip-pen nanolithography and related techniques like polymer pen lithography (PPL) for the site-specific chemical and bio-chemical modification of surfaces and devices.

The Scanning Probe Lithography for Biomaterials and Bioelectronics Group at INTOur research is aimed at the advancement and application of Scanning Probe Lithography (SPL) methods, in particular Dip-Pen Nanolithography (DPN) and related methods like e.g. Polymer Pen Lithography (PPL) and Microchannel Cantilever Spotting (µCS).

These SPL methods are versatile tools, combining many advantages of electron beam lithography, inkjet printing and microcontact printing in relation to resolution, integration and throughput. These methods are of particular interest when working with sensitive biological materials, since they work at mild process parameters and need no lift off processes (with the associated solvents or etching processes). Furthermore, the methods allows for "multiplexing", i.e. the parallel application of different inks within a pattern. Learn more about specific implementations and applications on our reseach page or browse our publications.


Vesicle Immobilization
Vesicle Immobilization:

"Stability of Immobilized Chemosensor-Filled Vesicles on Anti-Fouling Polymer Brush Surfaces" by Yang et al. in Adv. Mater. Interfaces 11 (2024)

Harsh Raj M. Hirtz
New Groupmember:

We welcome our new master student Harsh Raj!

Microarrays for MOSAIC

"Surface-Patterned DNA Origami Rulers Reveal Nanoscale Distance Dependency of the Epidermal Growth Factor Receptor Activation" by Mayer et al. in Nano Lett. 24 (2024) 1611

Scheme of MSP-POM immobilization
POM Immobilization:

"Patterned immobilization of polyoxometalate-loaded mesoporous silica particles via amine-ene Michael additions on alkene functionalized surfaces" by Yang et. al in Sci. Rep. 14 (2024) 1249

Printed Bioelectronics

"Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids" by Saghafi et al. in Adv. Funct. Mater. (2023) 2308613

Scheme of L-DPN on Nanoglass

"Nanoscale Confinement of Dip-Pen Nanolithography Written Phospholipid Structures on CuZr Nanoglasses" by Vasantham et al. in Adv. Mater. Interfaces 11 (2024) 2300721